The basic panel of analyses at Biotest Facility consists of the common hematology parameters including three-part differential counts and the clinical chemistry parameters ALB, ALT, BUN, Ca, CHOL, CREA, GLOB, Phos, TBIL and TP. Besides this cost-effective selection, we offer extensions to the panel and we are always open to study specific requirements.
Clinical adverse symptoms revealed in the preclinical development, e.g. during administration to rodent research models, are valuable indicators of issues that must be addressed during the further development. We always document the relevant clinical observations, with measurements of hematology parameters and clinical chemistry, during one of the very first administrations of the test article to an animal research model.
The mice have entered Biotest Facility and we will take good care of them. They will have a health check every day and they’re caged in an enriched environment with hidings, bedding, nesting material, biting sticks and chow & water ad libitum. The cages are ventilated individually, and the temperature is maintained between 20 and 24° C.
All animal studies are conducted according to Danish legislation and specific licenses issued by the Animal Experiments Inspectorate. Prospective and retrospective assessment of the interventions will be obtained individually for each animal and reported. The routine assessment and handling of the animals will be conducted by technicians, who are continuously training the procedures and are under supervision of a dedicated veterinarian.
Biotest Facility is committed to continuous implementation of the principles of 3R, which stands for “Replacement”, “Reduction” and “Refinement”. Replacement entails that Biotest Facility is committed to replace experiments with conscious living organisms with insentient materials, e.g. cell cultures or animal organs, whenever possible. Reduction entails that Biotest Facility is committed to reducing the number of animals used in experiments by careful planning and development of our analytical procedures, to gain more scientific value from each animal. Refinement entails that Biotest Facility is committed to increase the quality and to decrease the severity of the procedures applied to the animals used in an experiment.
Your provider of preclinical in vivo studies and tests.
Biotest Facility is a contract research organization conducting investigations in the field of preclinical pharmacology. The service includes design, conduct, and reporting of studies. The research models range from in vitro systems based on cells in culture to in vivo pharmacology in rodents. We offer classical pharmacology studies and integrated approaches, including mathematical modelling. We carry out pharmacodynamic, pharmacokinetic and toxicokinetic studies in combination with various disease models, and with a focus on oncology and radiochemicals. We also offer flexible and affordable solutions for facility management and rental of separate facility sections ideally equipped for pharmacology studies.
Biotest Facility is a new company with an experienced staff and extended network of suppliers and consultants from academia, biotech, and pharma industry. We pride ourselves of delivering accurate and cost-efficient solutions for validation of life science concepts, and for providing sound contributions to the early phase of drug development.