Xenograft Research Models – Rodents

No. 1 - mus på skjul

Cell line derived xenografts (CDX) in immunodeficient mice, as the BALB/c nude mice shown in the picture above, has been the most popular research model at Biotest Facility which also reflects that these models are representing the bulk of preclinical cancer research. We have added further knowledge to the accumulated experiences with these models, e.g. are these mice housed with various enrichment’s and in this case the bedding material is ALPHA-dri paper particles to reduce the dust production and then reducing contamination risk during handling of animals that are administrated with cytotoxic and radioactive test articles, furthermore is elimination of dust also enhancing the housing conditions for the hairless mouse. The pivotal efficacy read-out is the measurements of tumor growth rate inhibition associated with the medical treatment, the human tumor inoculated SC is measured with a digital Vernier Caliper, however, accompanying testing in these models, ranging from target validation to pharmacokinetics and toxicity tests are adding high value for use in the following preclinical and clinical phases of the development.

These studies are never of-the-self services, though are we offering very cost-effective standard set-up’s of low scale studies, e.g. to facilitate the pilot phase and validation/titration of a specific model for a Sponsor. Allow us to suggest a study design that is taking care of the specific challenges in the development program for your anti-cancer drug candidate.