Xenograft Research Models – Rodents

No. 1 - mus på skjul

Cell line derived xenografts (CDX) in immunodeficient mice, such as the BALB/c nude mice shown in the picture above, is the most popular research model at Biotest Facility. This reflects that these models also represent the bulk of preclinical cancer research. We have added further refinements based on our accumulated experiences with rodent models. For instance, our mice are housed with various enrichment’s and we use ALPHA-dri paper particle bedding material to reduce the dust production and subsequently contamination risk during handling. This is important when animals are administrated with cytotoxic or radioactive test articles. Furthermore, elimination of dust also enhances the housing quality for the hairless mice.

The pivotal efficacy read-out is the measurements of tumor growth rate inhibition associated with the medical treatment. The human tumor inoculated subcutaneously is measured with a digital Vernier caliper. However, accompanying testing in these models, ranging from target validation to pharmacokinetics and toxicity tests, offer increased value in the following preclinical and clinical phases of the development.

Our rodent studies are never of-the-shelf services, though we offer very cost-effective standard setups of low scale studies, e.g. to facilitate the pilot phase and for validation or titration of a specific model. Allow us to suggest a study design that takes care of the specific challenges in the development program for your anti-cancer drug candidate.